An RNA that multiplies indefinitely with DNA-dependent RNA polymerase: selection from a random copolymer.
نویسندگان
چکیده
We have selected from a mixture of random polynucleotides an RNA that is able to replicate in the presence of the DNA-dependent RNA polymerase of Escherichia coli, provided the medium contains Mn(2+) and ITP, in addition to ATP, CTP, and UTP. The RNA consists of a chain of about 125 (+/-25) nucleotides and appears to have a defined, nonrepetitive sequence.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 70 3 شماره
صفحات -
تاریخ انتشار 1973